Kidney Precision Medicine Center of Excellence (KPMCOE)

The KPMCOE was founded with the vision to transform the care of patients with kidney disease. To modernize clinical practice, the KPMCOE analyzes electronic health records, identifying barriers to care and implementing real-time digital tools to improve risk assessment or integrate quality improvement initiatives. Alongside clinical optimization, the KPMOCE aims to advance kidney disease research by improving the diagnosis and classification of patients with kidney disease and enrich enrollment in prospective trials or studies.

The KPMCOE repository of EPIC data on Hopkins Precision Medicine Analytic Platform (PMAP) consists of all patients with serum creatinine values ever checked at Johns Hopkins Hospital (1.7 million patients, 16 million serum creatinine values, 4 million inpatient records, 54 million outpatient contacts) from 2003 onwards. The database is subject to weekly updates, processing, and cleaning to create curated data tables for analysis.

The primary aims of KPMCOE include:

• Diagnosis and Prevention: Can improved clinical phenotyping aid in the early diagnosis and management of acute kidney injury? Can real-time interrogation of the electronic health record prevent iatrogenic kidney injury?
• Measure Outcomes: Can prevention of acute kidney injury reduce subsequent chronic kidney disease? Does a multipronged approach, including the implementation of risk tools in electronic medical records, lead to better outcomes in patients with kidney disease?
• Discovery: Can we efficiently identify opportunities for enrollment in clinical trials and biorepository registries that will lead to new discoveries for treatment and prevention?

More information can be found here.